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Periogen prevents and removes dental plaque and tartar buildup with each application. An independent study confirms a 45% reduction in plaque and tartar indexes when compared to brushing alone. Periogen is non acidic with a healthy 7.5 pH. contains no alcohol, bleach, or triclosan. and will not harm enamel or dental appliances. One 3oz. bottle of Periogen makes over 2 gallons of rinse (45 day supply). Periogen study results were presented at FDI the World Dental Congress in September 2015 and at 45th American Association for Dental Research (AADR) in March 2016. Periogen has been included in 7 research publications. The time required to remove tartar varies depending upon age and tenacity of tartar.